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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Asymmetric parental genome engineering by Cas9 during mouse meiotic exit
|
|---|---|
| Published in |
Scientific Reports, December 2014
|
| DOI | 10.1038/srep07621 |
| Pubmed ID | |
| Authors |
Toru Suzuki, Maki Asami, Anthony C. F. Perry |
| Abstract |
Mammalian genomes can be edited by injecting pronuclear embryos with Cas9 cRNA and guide RNA (gRNA) but it is unknown whether editing can also occur during the onset of embryonic development, prior to pronuclear embryogenesis. We here report Cas9-mediated editing during sperm-induced meiotic exit and the initiation of development. Injection of unfertilized, mouse metaphase II (mII) oocytes with Cas9 cRNA, gRNA and sperm enabled efficient editing of transgenic and native alleles. Pre-loading oocytes with Cas9 increased sensitivity to gRNA ~100-fold. Paternal allelic editing occurred as an early event: single embryo genome analysis revealed editing within 3 h of sperm injection, coinciding with sperm chromatin decondensation during the gamete-to-embryo transition but prior to pronucleus formation. Maternal alleles underwent editing after the first round of DNA replication, resulting in mosaicism. Asymmetric editing of maternal and paternal alleles suggests a novel strategy for discriminatory targeting of parental genomes. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| United Kingdom | 3 | 19% |
| France | 2 | 13% |
| Israel | 1 | 6% |
| Germany | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 4 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 88% |
| Scientists | 1 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| China | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 92 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 23% |
| Student > Bachelor | 22 | 23% |
| Student > Ph. D. Student | 14 | 14% |
| Student > Master | 13 | 13% |
| Professor > Associate Professor | 5 | 5% |
| Other | 10 | 10% |
| Unknown | 11 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 32% |
| Agricultural and Biological Sciences | 31 | 32% |
| Medicine and Dentistry | 7 | 7% |
| Social Sciences | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 9 | 9% |
| Unknown | 15 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 113. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2017.
All research outputs
#383,997
of 25,954,278 outputs
Outputs from Scientific Reports
#4,263
of 144,104 outputs
Outputs of similar age
#4,343
of 362,113 outputs
Outputs of similar age from Scientific Reports
#24
of 980 outputs
Altmetric has tracked 25,954,278 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 144,104 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,113 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 980 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.