Title |
Function by Structure: Spotlights on Xist Long Non-coding RNA
|
---|---|
Published in |
Frontiers in Molecular Biosciences, December 2017
|
DOI | 10.3389/fmolb.2017.00090 |
Pubmed ID | |
Authors |
Greta Pintacuda, Alexander N. Young, Andrea Cerase |
Abstract |
Recent experimental evidence indicates that lncRNAs can act as regulatory molecules in the context of development and disease. Xist, the master regulator of X chromosome inactivation, is a classic example of how lncRNAs can exert multi-layered and fine-tuned regulatory functions, by acting as a molecular scaffold for recruitment of distinct protein factors. In this review, we discuss the methodologies employed to define Xist RNA structures and the tight interplay between structural clues and functionality of lncRNAs. This model of modular function dictated by structure, can be also generalized to other lncRNAs, beyond the field of X chromosome inactivation, to explain common features of similarly folded RNAs. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 135 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 26% |
Researcher | 20 | 15% |
Student > Bachelor | 20 | 15% |
Student > Master | 10 | 7% |
Professor > Associate Professor | 4 | 3% |
Other | 10 | 7% |
Unknown | 36 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 59 | 44% |
Agricultural and Biological Sciences | 16 | 12% |
Medicine and Dentistry | 4 | 3% |
Immunology and Microbiology | 3 | 2% |
Computer Science | 3 | 2% |
Other | 11 | 8% |
Unknown | 39 | 29% |