Title |
Non-Genomic Androgen Action Regulates Proliferative/Migratory Signaling in Stromal Cells
|
---|---|
Published in |
Frontiers in endocrinology, January 2015
|
DOI | 10.3389/fendo.2014.00225 |
Pubmed ID | |
Authors |
Marzia Di Donato, Pia Giovannelli, Gustavo Cernera, Annalisa Di Santi, Irene Marino, Antonio Bilancio, Giovanni Galasso, Ferdinando Auricchio, Antimo Migliaccio, Gabriella Castoria |
Abstract |
Prostate cancer (PCa) is the major cause of cancer-related death among the male population of Western society, and androgen-deprivation therapy (ADT) represents the first line in PCa treatment. However, although androgen receptor (AR) expression is maintained throughout the various stages of PCa, ADT frequently fails. Clinical studies have demonstrated that different androgen/AR signaling pathways operate in target tissues. AR stimulates growth and transformation of target cells, but under certain conditions slows down their proliferation. In this review, we discuss the role of AR in controlling different functions of mesenchymal and transformed mesenchymal cells. Findings here presented support the role of AR in suppressing proliferation and stimulating migration of stromal cells, with implications for current approaches to cancer therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Bachelor | 2 | 6% |
Student > Master | 2 | 6% |
Other | 6 | 19% |
Unknown | 11 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 29% |
Agricultural and Biological Sciences | 5 | 16% |
Medicine and Dentistry | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 39% |