Title |
mTOR Links Environmental Signals to T Cell Fate Decisions
|
---|---|
Published in |
Frontiers in immunology, January 2015
|
DOI | 10.3389/fimmu.2014.00686 |
Pubmed ID | |
Authors |
Nicole M. Chapman, Hongbo Chi |
Abstract |
T cell fate decisions play an integral role in maintaining the health of organisms under homeostatic and inflammatory conditions. The localized microenvironment in which developing and mature T cells reside provides signals that serve essential functions in shaping these fate decisions. These signals are derived from the immune compartment, including antigens, co-stimulation, and cytokines, and other factors, including growth factors and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within the immune microenvironment, is a central regulator of T cell biology. In this review, we discuss how various environmental cues tune mTOR activity in T cells, and summarize how mTOR integrates these signals to influence multiple aspects of T cell biology. |
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Geographical breakdown
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