Title |
Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How?
|
---|---|
Published in |
Frontiers in endocrinology, February 2018
|
DOI | 10.3389/fendo.2018.00008 |
Pubmed ID | |
Authors |
Mark Quinn, Amar Agha |
Abstract |
Traumatic brain injury (TBI) remains a major, global public health concern. Over the last 15 years, a significant body of evidence has emerged demonstrating that post-traumatic hypopituitarism (PTHP) is a common and clinically significant consequence of TBI. Non-specific symptomology and the lack of an agreed approach to screening for PTHP has led to significant under-diagnosis of this debilitating disease. In this review, we will discuss the frequency and clinical significance of acute and chronic PTHP as described in the current literature highlighting the evidence base for screening and hormone replacement in these patients. We will also offer a pragmatic approach to identifying relevant anterior pituitary dysfunction after TBI and a follow-up strategy for those patients. Specific controversies and remaining unanswered questions will be addressed. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 14% |
United States | 1 | 14% |
Saudi Arabia | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 18% |
Student > Ph. D. Student | 4 | 12% |
Researcher | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Other | 6 | 18% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 41% |
Neuroscience | 3 | 9% |
Environmental Science | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Sports and Recreations | 1 | 3% |
Other | 3 | 9% |
Unknown | 10 | 29% |