Title |
Marine Fungi: A Source of Potential Anticancer Compounds
|
---|---|
Published in |
Frontiers in Microbiology, January 2018
|
DOI | 10.3389/fmicb.2017.02536 |
Pubmed ID | |
Authors |
Sunil K. Deshmukh, Ved Prakash, Nihar Ranjan |
Abstract |
Metabolites from marine fungi have hogged the limelight in drug discovery because of their promise as therapeutic agents. A number of metabolites related to marine fungi have been discovered from various sources which are known to possess a range of activities as antibacterial, antiviral and anticancer agents. Although, over a thousand marine fungi based metabolites have already been reported, none of them have reached the market yet which could partly be related to non-comprehensive screening approaches and lack of sustained lead optimization. The origin of these marine fungal metabolites is varied as their habitats have been reported from various sources such as sponge, algae, mangrove derived fungi, and fungi from bottom sediments. The importance of these natural compounds is based on their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them. This review covers the majority of anticancer compounds isolated from marine fungi during 2012-2016 against specific cancer cell lines. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 6% |
Switzerland | 3 | 5% |
Nigeria | 3 | 5% |
United States | 3 | 5% |
Mexico | 2 | 3% |
India | 2 | 3% |
Chile | 2 | 3% |
Germany | 1 | 2% |
Italy | 1 | 2% |
Other | 14 | 22% |
Unknown | 28 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 51 | 81% |
Scientists | 9 | 14% |
Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 265 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 36 | 14% |
Student > Bachelor | 36 | 14% |
Researcher | 25 | 9% |
Student > Ph. D. Student | 25 | 9% |
Student > Doctoral Student | 10 | 4% |
Other | 32 | 12% |
Unknown | 101 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 17% |
Agricultural and Biological Sciences | 35 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 6% |
Chemistry | 16 | 6% |
Immunology and Microbiology | 15 | 6% |
Other | 25 | 9% |
Unknown | 113 | 43% |