Title |
How Do Structurally Distinct Compounds Exert Functionally Identical Effects in Combating Obesity?
|
---|---|
Published in |
Frontiers in Pharmacology, February 2018
|
DOI | 10.3389/fphar.2018.00069 |
Pubmed ID | |
Authors |
Zhi-Jun Deng, Ruo-Xuan Liu, A-Rong Li, Jie-Wen Guo, Qing-Ping Zeng |
Abstract |
Although the concept of inflammatory obesity remains to be widely accepted, a plethora of antibiotics, anti-inflammatory agents, mitochondrial uncouplers, and other structurally distinct compounds with unknown mechanisms have been demonstrated to exert functionally identical effects on weight reduction. Here we summarize a universal mechanism in which weight loss is modulated by mitochondrial biogenesis, which is correlated with conversion from the mitochondria-insufficient white adipose tissue to the mitochondria-abundant brown adipose tissue. This mechanistic description of inflammatory obesity may prove useful in the future for guiding pathology-based drug discovery for weight reduction. |
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Other | 1 | 8% |
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