Title |
Uterine Microbiota: Residents, Tourists, or Invaders?
|
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Published in |
Frontiers in immunology, March 2018
|
DOI | 10.3389/fimmu.2018.00208 |
Pubmed ID | |
Authors |
James M. Baker, Dana M. Chase, Melissa M. Herbst-Kralovetz |
Abstract |
Uterine microbiota have been reported under various conditions and populations; however, it is uncertain the level to which these bacteria are residents that maintain homeostasis, tourists that are readily eliminated or invaders that contribute to human disease. This review provides a historical timeline and summarizes the current status of this topic with the aim of promoting research priorities and discussion on this controversial topic. Discrepancies exist in current reports of uterine microbiota and are critically reviewed and examined. Established and putative routes of bacterial seeding of the human uterus and interactions with distal mucosal sites are discussed. Based upon the current literature, we highlight the need for additional robust clinical and translational studies in this area. In addition, we discuss the necessity for investigating host-microbiota interactions and the physiologic and functional impact of these microbiota on the local endometrial microenvironment as these mechanisms may influence poor reproductive, obstetric, and gynecologic health outcomes and sequelae. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 6 | 22% |
Ecuador | 2 | 7% |
United States | 1 | 4% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Ireland | 1 | 4% |
Unknown | 16 | 59% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 52% |
Scientists | 9 | 33% |
Practitioners (doctors, other healthcare professionals) | 4 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 392 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 51 | 13% |
Student > Bachelor | 45 | 11% |
Student > Master | 39 | 10% |
Student > Ph. D. Student | 35 | 9% |
Student > Doctoral Student | 20 | 5% |
Other | 53 | 14% |
Unknown | 149 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 62 | 16% |
Biochemistry, Genetics and Molecular Biology | 54 | 14% |
Agricultural and Biological Sciences | 30 | 8% |
Immunology and Microbiology | 27 | 7% |
Veterinary Science and Veterinary Medicine | 13 | 3% |
Other | 33 | 8% |
Unknown | 173 | 44% |