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Mendeley readers
Title |
Inducible and combinatorial gene manipulation in mouse brain
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Published in |
Frontiers in Cellular Neuroscience, April 2015
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DOI | 10.3389/fncel.2015.00142 |
Pubmed ID | |
Authors |
Godwin K. Dogbevia, Ricardo Marticorena-Alvarez, Melanie Bausen, Rolf Sprengel, Mazahir T. Hasan |
Abstract |
We have deployed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate 'when', 'where', and 'how' gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 73 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 32% |
Student > Master | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 4 | 5% |
Other | 4 | 5% |
Unknown | 13 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 21 | 28% |
Agricultural and Biological Sciences | 14 | 19% |
Biochemistry, Genetics and Molecular Biology | 13 | 18% |
Medicine and Dentistry | 4 | 5% |
Immunology and Microbiology | 2 | 3% |
Other | 5 | 7% |
Unknown | 15 | 20% |