Prabuddha S. Pathinayake, Alan C.-Y. Hsu, David W. Waters, Philip M. Hansbro, Lisa G. Wood, Peter A. B. Wark
Abstract
Asthma is a heterogeneous, chronic inflammatory disease of the airways. It is a complex disease with different clinical phenotypes and results in a substantial socioeconomic burden globally. Poor understanding of pathogenic mechanisms of the disease hinders the investigation into novel therapeutics. Emerging evidence of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) has demonstrated previously unknown functions of this response in asthma development. A worsening of asthmatic condition can be brought on by stimuli such as oxidative stress, pathogenic infections, and allergen exposure. All of which can induce ER stress and activate UPR leading to activation of different inflammatory responses and dysregulate the innate immune functions in the airways. The UPR as a central regulator of asthma pathogenesis may explain several unknown mechanism of the disease onset, which leads us in new directions for future asthma treatments. In this review, we summarize and discuss the causes and impact of ER-UPR in driving the pathogenesis of asthma and highlight its importance in clinical implications.
Pharmacology, Toxicology and Pharmaceutical Science
4
5%
Medicine and Dentistry
4
5%
Other
9
12%
Unknown
21
29%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#3,489,488
of 26,626,138 outputs
Outputs from Frontiers in immunology
#3,902
of 33,426 outputs
Outputs of similar age
#73,009
of 452,975 outputs
Outputs of similar age from Frontiers in immunology
#110
of 621 outputs
Altmetric has tracked 26,626,138 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,426 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,975 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 621 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.
