Title |
6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells
|
---|---|
Published in |
Frontiers in Pharmacology, February 2018
|
DOI | 10.3389/fphar.2018.00159 |
Pubmed ID | |
Authors |
Xiao Li, Jingting Guo, Ning Liang, Xinwei Jiang, Yuan Song, Shiyi Ou, Yunfeng Hu, Rui Jiao, Weibin Bai |
Abstract |
Gingerols, the pungent ingredients in ginger, are reported to possess a cholesterol-lowering activity. However, the underlying mechanism remains unclear. The present study was to investigate how 6-gingerol (6-GN), the most abundant gingerol in fresh ginger, regulates hepatic cholesterol metabolism. HepG2 cells were incubated with various concentrations of 6-GN ranging from 50 to 200 μM for 24 h. Results showed that both cellular total cholesterol and free cholesterol decreased in a dose-dependent manner. Besides, 6-GN ranging from 100 to 200 μM increased the LDLR protein and uptake of fluorescent-labeled LDL. Moreover, the mRNA and protein expressions of cholesterol metabolism-related genes were also examined. It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRα and ABCA1. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 12% |
Student > Postgraduate | 3 | 7% |
Student > Bachelor | 3 | 7% |
Lecturer > Senior Lecturer | 2 | 5% |
Lecturer | 2 | 5% |
Other | 7 | 17% |
Unknown | 19 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 20% |
Agricultural and Biological Sciences | 6 | 15% |
Medicine and Dentistry | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Social Sciences | 1 | 2% |
Other | 3 | 7% |
Unknown | 19 | 46% |