Title |
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
|
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Published in |
Glycobiology, May 2007
|
DOI | 10.1093/glycob/cwm049 |
Pubmed ID | |
Authors |
Takashi Angata, Yukako Tabuchi, Kazunori Nakamura, Mitsuru Nakamura |
Abstract |
Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail. Siglec-15 is expressed on macrophages and/or dendritic cells of human spleen and lymph nodes. We show that the extracellular domain of Siglec-15 preferentially recognizes the Neu5Acalpha2-6GalNAcalpha- structure. Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule. Siglec-15 is the second human Siglec identified to have an activating signaling potential; unlike Siglec-14, however, it does not have an inhibitory counterpart. Orthologs of Siglec-15 are present not only in mammals but also in other branches of vertebrates; in contrast, no other known Siglec expressed in the immune system has been conserved throughout vertebrate evolution. Thus, Siglec-15 probably plays a conserved, regulatory role in the immune system of vertebrates. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 138 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 16% |
Student > Master | 20 | 14% |
Student > Bachelor | 15 | 11% |
Researcher | 15 | 11% |
Student > Postgraduate | 14 | 10% |
Other | 16 | 12% |
Unknown | 36 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 22% |
Agricultural and Biological Sciences | 28 | 20% |
Immunology and Microbiology | 14 | 10% |
Medicine and Dentistry | 10 | 7% |
Chemistry | 8 | 6% |
Other | 9 | 7% |
Unknown | 39 | 28% |