The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
| Title |
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution
|
|---|---|
| Published in |
Glycobiology, May 2007
|
| DOI | 10.1093/glycob/cwm049 |
| Pubmed ID | |
| Authors |
Takashi Angata, Yukako Tabuchi, Kazunori Nakamura, Mitsuru Nakamura |
| Abstract |
Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail. Siglec-15 is expressed on macrophages and/or dendritic cells of human spleen and lymph nodes. We show that the extracellular domain of Siglec-15 preferentially recognizes the Neu5Acalpha2-6GalNAcalpha- structure. Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule. Siglec-15 is the second human Siglec identified to have an activating signaling potential; unlike Siglec-14, however, it does not have an inhibitory counterpart. Orthologs of Siglec-15 are present not only in mammals but also in other branches of vertebrates; in contrast, no other known Siglec expressed in the immune system has been conserved throughout vertebrate evolution. Thus, Siglec-15 probably plays a conserved, regulatory role in the immune system of vertebrates. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 16% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 15 | 11% |
| Researcher | 15 | 11% |
| Student > Postgraduate | 14 | 10% |
| Other | 16 | 12% |
| Unknown | 36 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 22% |
| Agricultural and Biological Sciences | 28 | 20% |
| Immunology and Microbiology | 14 | 10% |
| Medicine and Dentistry | 10 | 7% |
| Chemistry | 8 | 6% |
| Other | 9 | 7% |
| Unknown | 39 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2023.
All research outputs
#1,630,858
of 26,313,853 outputs
Outputs from Glycobiology
#35
of 2,100 outputs
Outputs of similar age
#3,172
of 87,449 outputs
Outputs of similar age from Glycobiology
#1
of 14 outputs
Altmetric has tracked 26,313,853 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,100 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 87,449 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.