Title |
Synthesis, Characterization, and Handling of EuII-Containing Complexes for Molecular Imaging Applications
|
---|---|
Published in |
Frontiers in Chemistry, March 2018
|
DOI | 10.3389/fchem.2018.00065 |
Pubmed ID | |
Authors |
Lina A. Basal, Matthew J. Allen |
Abstract |
Considerable research effort has focused on thein vivouse of responsive imaging probes that change imaging properties upon reacting with oxygen because hypoxia is relevant to diagnosing, treating, and monitoring diseases. One promising class of compounds for oxygen-responsive imaging is EuII-containing complexes because the EuII/IIIredox couple enables imaging with multiple modalities including magnetic resonance and photoacoustic imaging. The use of EuIIrequires care in handling to avoid unintended oxidation during synthesis and characterization. This review describes recent advances in the field of imaging agents based on discrete EuII-containing complexes with specific focus on the synthesis, characterization, and handling of aqueous EuII-containing complexes. |
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