RT @renesugar: Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmiss…
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https://t.co/mDfcALmym7 "Overall, our results uncovered an implication of Fxr1 and its regulator Gsk3β in the control of synaptic components of glutamatergic neurotransmission."
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https://t.co/mDfcALmym7 "Changes in AMPA receptor subunits were accompanied with a decrease in vesicular glutamate transporter 1 (Vglut1) indicating pre- and post-synaptic changes of glutamatergic neurotransmission."
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https://t.co/mDfcALmym7 "Further investigation of underlying mechanism revealed that increase in Fxr1 and decrease in Gsk3β expression leads to AMPA receptor composition change most likely due to alteration of trafficking of both synaptic GluA1 and GluA2