Title |
The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity
|
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Published in |
Frontiers in Microbiology, March 2018
|
DOI | 10.3389/fmicb.2018.00485 |
Pubmed ID | |
Authors |
Anna Kloc, Devendra K., Elizabeth Rieder |
Abstract |
Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute to initiation and progression of disease. Accumulated work in picornaviruses has stressed out the importance of the noncoding RNAs, or untranslated 5'- and 3'-regions (UTRs), in both replication and translation of viral genomes. Unsurprisingly, defects in these processes have been reported to cause viral attenuation and affect viral pathogenicity. However, substantial evidence suggests that these untranslated RNAs may influence the outcome of the host innate immune response. This review discusses the involvement of 5'- and 3'-terminus UTRs in induction and regulation of host immunity and its consequences for viral life cycle and virulence. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 21% |
Researcher | 12 | 18% |
Student > Master | 8 | 12% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 6 | 9% |
Unknown | 18 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 22% |
Agricultural and Biological Sciences | 14 | 21% |
Immunology and Microbiology | 8 | 12% |
Veterinary Science and Veterinary Medicine | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 6 | 9% |
Unknown | 21 | 31% |