Chapter title |
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase
|
---|---|
Chapter number | 18 |
Book title |
Huntington’s Disease
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7825-0_18 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7824-3, 978-1-4939-7825-0
|
Authors |
Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini, Sathyasaikumar, Korrapati V., Breda, Carlo, Schwarcz, Robert, Giorgini, Flaviano |
Abstract |
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally. |
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