Title |
Genomic-scale prioritization of drug targets: the TDR Targets database
|
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Published in |
Nature Reviews Drug Discovery, October 2008
|
DOI | 10.1038/nrd2684 |
Pubmed ID | |
Authors |
Fernán Agüero, Bissan Al-Lazikani, Martin Aslett, Matthew Berriman, Frederick S. Buckner, Robert K. Campbell, Santiago Carmona, Ian M. Carruthers, A. W. Edith Chan, Feng Chen, Gregory J. Crowther, Maria A. Doyle, Christiane Hertz-Fowler, Andrew L. Hopkins, Gregg McAllister, Solomon Nwaka, John P. Overington, Arnab Pain, Gaia V. Paolini, Ursula Pieper, Stuart A. Ralph, Aaron Riechers, David S. Roos, Andrej Sali, Dhanasekaran Shanmugam, Takashi Suzuki, Wesley C. Van Voorhis, Christophe L. M. J. Verlinde |
Abstract |
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 7 | 2% |
United Kingdom | 6 | 2% |
United States | 5 | 2% |
Germany | 2 | <1% |
India | 2 | <1% |
Turkey | 1 | <1% |
Austria | 1 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Other | 10 | 3% |
Unknown | 284 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 71 | 22% |
Student > Ph. D. Student | 57 | 18% |
Student > Master | 42 | 13% |
Professor > Associate Professor | 22 | 7% |
Student > Doctoral Student | 21 | 7% |
Other | 64 | 20% |
Unknown | 43 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 105 | 33% |
Biochemistry, Genetics and Molecular Biology | 43 | 13% |
Medicine and Dentistry | 33 | 10% |
Chemistry | 31 | 10% |
Immunology and Microbiology | 12 | 4% |
Other | 40 | 13% |
Unknown | 56 | 18% |