Title |
Nephrolithiasis and Nephrocalcinosis in Childhood—Risk Factor-Related Current and Future Treatment Options
|
---|---|
Published in |
Frontiers in Pediatrics, April 2018
|
DOI | 10.3389/fped.2018.00098 |
Pubmed ID | |
Authors |
Alexander Weigert, Bernd Hoppe |
Abstract |
Nephrolithiasis, urolithiasis, and nephrocalcinosis (NC) have become common causes of hospitalization and referral to pediatric outpatient clinics. It is of utmost importance to start with diagnostic evaluation directly after the first passage of a kidney stone, or if NC is diagnosed, in each pediatric patient. This is necessary, as in about 80% of children a metabolic reason for stone disease is detected. Current treatment options are scarce and mainly include general measures like an increased fluid intake or elevating the solubility of a lithogenic substance. According to the given lithogenic risk factor(s), specific treatment options are available and are being summarized in this review. Furthermore, an outlook on potential future treatment options, including innovative strategies such as mRNA-based or recombinant enzyme substitution therapy, is given. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Thailand | 1 | 6% |
Switzerland | 1 | 6% |
Venezuela, Bolivarian Republic of | 1 | 6% |
Iceland | 1 | 6% |
Unknown | 12 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 13 | 81% |
Science communicators (journalists, bloggers, editors) | 2 | 13% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 6 | 11% |
Other | 5 | 9% |
Professor > Associate Professor | 5 | 9% |
Student > Master | 4 | 7% |
Other | 8 | 15% |
Unknown | 20 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 48% |
Nursing and Health Professions | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Mathematics | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Other | 1 | 2% |
Unknown | 22 | 41% |