Title |
Chronic shifts in the length and phase of the light cycle increase intermittent alcohol drinking in C57BL/6J mice
|
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Published in |
Frontiers in Behavioral Neuroscience, February 2015
|
DOI | 10.3389/fnbeh.2015.00009 |
Pubmed ID | |
Authors |
Joshua J. Gamsby, Danielle Gulick |
Abstract |
Shift workers-e.g., health care professionals, truck drivers, and factory workers-are forced to maintain daily cycles at odds with their natural circadian rhythms and as a consequence need to frequently readjust these cycles. This shift work-induced circadian desynchrony (CD) is associated with increased sleep disorders and with alcohol abuse. Nonetheless, it has proven difficult to model CD-induced changes in alcohol consumption in mouse models, which is an important step toward identifying the mechanisms by which CD increases alcohol intake. This study examined whether frequent changes in the light cycle could increase free access alcohol intake in a mouse line that readily consumes alcohol. |
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