Title |
Non-coding RNA in neural function, disease, and aging
|
---|---|
Published in |
Frontiers in Genetics, January 2015
|
DOI | 10.3389/fgene.2015.00087 |
Pubmed ID | |
Authors |
Kirk Szafranski, Karan J. Abraham, Karim Mekhail |
Abstract |
Declining brain and neurobiological function is arguably one of the most common features of human aging. The study of conserved aging processes as well as the characterization of various neurodegenerative diseases using different genetic models such as yeast, fly, mouse, and human systems is uncovering links to non-coding RNAs. These links implicate a variety of RNA-regulatory processes, including microRNA function, paraspeckle formation, RNA-DNA hybrid regulation, nucleolar RNAs and toxic RNA clearance, amongst others. Here we highlight these connections and reveal over-arching themes or questions related to recently appreciated roles of non-coding RNA in neural function and dysfunction across lifespan. |
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France | 2 | 33% |
India | 2 | 33% |
Switzerland | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
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Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 167 | 97% |
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Readers by professional status | Count | As % |
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Researcher | 40 | 23% |
Student > Master | 15 | 9% |
Student > Bachelor | 13 | 8% |
Student > Doctoral Student | 13 | 8% |
Other | 31 | 18% |
Unknown | 19 | 11% |
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Medicine and Dentistry | 16 | 9% |
Neuroscience | 16 | 9% |
Computer Science | 2 | 1% |
Other | 9 | 5% |
Unknown | 23 | 13% |