Title |
Systemic administration of local anesthetic agents to relieve neuropathic pain
|
---|---|
Published in |
Cochrane database of systematic reviews, October 2005
|
DOI | 10.1002/14651858.cd003345.pub2 |
Pubmed ID | |
Authors |
Vidya Challapalli, Ivo W Tremont-Lukats, Ewan D McNicol, Joseph Lau, Daniel B Carr |
Abstract |
Lidocaine, mexiletine, tocainide, and flecainide are local anesthetics which give an analgesic effect when administered orally or parenterally. Early reports described the use of intravenous lidocaine or procaine to relieve cancer and postoperative pain (Keats 1951; Gilbert 1951; De Clive-Lowe 1958; Bartlett 1961). Interest reappeared decades later when patient series and clinical trials reported that parenteral lidocaine and its oral analogs tocainide, mexiletine, and flecainide relieved neuropathic pain in some patients (Boas 1982; Lindblom 1984; Petersen 1986; Dunlop 1988; Bach 1990; Awerbuch 1990). With the recent publication of clinical trials with high quality standards, we have reviewed the use of systemic lidocaine and its oral analogs in neuropathic pain to update our knowledge, to measure their benefit and harm, and to better define their role in therapy. |
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Country | Count | As % |
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Canada | 4 | 25% |
United Kingdom | 4 | 25% |
Spain | 2 | 13% |
Mexico | 1 | 6% |
India | 1 | 6% |
Australia | 1 | 6% |
Colombia | 1 | 6% |
Unknown | 2 | 13% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 63% |
Scientists | 4 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
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Switzerland | 1 | <1% |
Australia | 1 | <1% |
Hong Kong | 1 | <1% |
Japan | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 275 | 97% |
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Researcher | 32 | 11% |
Other | 28 | 10% |
Student > Ph. D. Student | 28 | 10% |
Student > Postgraduate | 27 | 10% |
Student > Master | 26 | 9% |
Other | 64 | 23% |
Unknown | 78 | 28% |
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Psychology | 11 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Agricultural and Biological Sciences | 8 | 3% |
Other | 33 | 12% |
Unknown | 84 | 30% |