Title |
Insulin signaling is acutely required for long-term memory in Drosophila
|
---|---|
Published in |
Frontiers in Neural Circuits, March 2015
|
DOI | 10.3389/fncir.2015.00008 |
Pubmed ID | |
Authors |
Daniel B. Chambers, Alaura Androschuk, Cory Rosenfelt, Steven Langer, Mark Harding, Francois V. Bolduc |
Abstract |
Memory formation has been shown recently to be dependent on energy status in Drosophila. A well-established energy sensor is the insulin signaling (InS) pathway. Previous studies in various animal models including human have revealed the role of insulin levels in short-term memory but its role in long-term memory remains less clear. We therefore investigated genetically the spatial and temporal role of InS using the olfactory learning and long-term memory model in Drosophila. We found that InS is involved in both learning and memory. InS in the mushroom body is required for learning and long-term memory whereas long-term memory specifically is impaired after InS signaling disruption in the ellipsoid body, where it regulates the level of p70s6k, a downstream target of InS and a marker of protein synthesis. Finally, we show also that InS is acutely required for long-term memory formation in adult flies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
United Kingdom | 1 | 2% |
Japan | 1 | 2% |
Unknown | 62 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 20% |
Student > Ph. D. Student | 10 | 15% |
Student > Master | 9 | 14% |
Student > Bachelor | 8 | 12% |
Student > Doctoral Student | 5 | 8% |
Other | 9 | 14% |
Unknown | 12 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 18 | 27% |
Agricultural and Biological Sciences | 17 | 26% |
Biochemistry, Genetics and Molecular Biology | 12 | 18% |
Unspecified | 2 | 3% |
Psychology | 1 | 2% |
Other | 2 | 3% |
Unknown | 14 | 21% |