Title |
The gut microbiome in cardio-metabolic health
|
---|---|
Published in |
Genome Medicine, March 2015
|
DOI | 10.1186/s13073-015-0157-z |
Pubmed ID | |
Authors |
Tue H Hansen, Rikke J Gøbel, Torben Hansen, Oluf Pedersen |
Abstract |
With the prevalence of cardio-metabolic disorders reaching pandemic proportions, the search for modifiable causative factors has intensified. One such potential factor is the vast microbial community inhabiting the human gastrointestinal tract, the gut microbiota. For the past decade evidence has accumulated showing the association of distinct changes in gut microbiota composition and function with obesity, type 2 diabetes and cardiovascular disease. Although causality in humans and the pathophysiological mechanisms involved have yet to be decisively established, several studies have demonstrated that the gut microbiota, as an environmental factor influencing the metabolic state of the host, is readily modifiable through a variety of interventions. In this review we provide an overview of the development of the gut microbiome and its compositional and functional changes in relation to cardio-metabolic disorders, and give an update on recent progress in how this could be exploited in microbiota-based therapeutics. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 25% |
United Kingdom | 5 | 21% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Switzerland | 1 | 4% |
Denmark | 1 | 4% |
Ecuador | 1 | 4% |
Italy | 1 | 4% |
Unknown | 8 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 50% |
Scientists | 8 | 33% |
Practitioners (doctors, other healthcare professionals) | 4 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
France | 1 | <1% |
Uruguay | 1 | <1% |
United Arab Emirates | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Greece | 1 | <1% |
Russia | 1 | <1% |
Unknown | 280 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 43 | 15% |
Student > Master | 41 | 14% |
Researcher | 40 | 14% |
Student > Bachelor | 28 | 10% |
Other | 20 | 7% |
Other | 62 | 21% |
Unknown | 55 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 58 | 20% |
Agricultural and Biological Sciences | 56 | 19% |
Biochemistry, Genetics and Molecular Biology | 39 | 13% |
Immunology and Microbiology | 19 | 7% |
Nursing and Health Professions | 18 | 6% |
Other | 31 | 11% |
Unknown | 68 | 24% |