Title |
Discovering Che-1/AATF: a new attractive target for cancer therapy
|
---|---|
Published in |
Frontiers in Genetics, April 2015
|
DOI | 10.3389/fgene.2015.00141 |
Pubmed ID | |
Authors |
Simona Iezzi, Maurizio Fanciulli |
Abstract |
The transcriptional cofactor Che-1/AATF is currently emerging as an important component of the DNA damage response (DDR) machinery, the complex signaling network that maintains genome integrity and prevents tumorigenesis. Moreover this protein is involved in a wide range of cellular pathways, regulating proliferation and survival in both physiological and pathological conditions. Notably, some evidence indicates that dysregulation of Che-1/AATF levels are associated with the transformation process and elevated levels of Che-1/AATF are required for tumor cell survival. It is for these reasons that Che-1/AATF has been regarded as an attractive, still theoretical, therapeutic target for cancer treatments. In this review, we will provide an updated overview of Che-1/AATF activities, from transcriptional regulation to DDR. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Denmark | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 26% |
Researcher | 5 | 15% |
Student > Bachelor | 5 | 15% |
Student > Master | 4 | 12% |
Student > Doctoral Student | 3 | 9% |
Other | 3 | 9% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 35% |
Biochemistry, Genetics and Molecular Biology | 9 | 26% |
Medicine and Dentistry | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Computer Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 5 | 15% |