Title |
Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance
|
---|---|
Published in |
Frontiers in endocrinology, April 2018
|
DOI | 10.3389/fendo.2018.00144 |
Pubmed ID | |
Authors |
Andrea del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuña-Castillo, Rodrigo Troncoso, Leonel E. Rojo |
Abstract |
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells. We believe that this approach may offer a valuable path to explain SGAs-induced alterations in metabolic homeostasis. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 80 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 10% |
Student > Ph. D. Student | 7 | 9% |
Researcher | 7 | 9% |
Student > Master | 7 | 9% |
Other | 5 | 6% |
Other | 15 | 19% |
Unknown | 31 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Agricultural and Biological Sciences | 4 | 5% |
Nursing and Health Professions | 3 | 4% |
Other | 10 | 13% |
Unknown | 37 | 46% |