Title |
Acute Myeloid Leukemia in Infants: Biology and Treatment
|
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Published in |
Frontiers in Pediatrics, April 2015
|
DOI | 10.3389/fped.2015.00037 |
Pubmed ID | |
Authors |
Riccardo Masetti, Francesca Vendemini, Daniele Zama, Carlotta Biagi, Andrea Pession, Franco Locatelli |
Abstract |
Children aged 0-2 years (i.e., infants) with acute myeloid leukemia (AML) are a peculiar subgroup of patients in the childhood AML scenario. They present with distinctive biological and clinical characteristics, including a high prevalence of prognostically unfavorable risk factors and an increased susceptibility to therapy-related toxicity. Remarkable improvements have been achieved over the last two decades in the treatment of these patients and their outcome is becoming superimposable to that of the older age groups. In this review, we will focus on peculiarities of this young subgroup of children with AML, describing their clinical presentation, the biology of disease, and factors influencing outcome. Treatment results and toxicity data reported by major collaborative groups are also summarized and compared. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 1% |
Unknown | 90 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 16% |
Student > Bachelor | 14 | 15% |
Other | 12 | 13% |
Researcher | 10 | 11% |
Student > Ph. D. Student | 9 | 10% |
Other | 18 | 20% |
Unknown | 13 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 34% |
Biochemistry, Genetics and Molecular Biology | 18 | 20% |
Agricultural and Biological Sciences | 17 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Engineering | 2 | 2% |
Other | 4 | 4% |
Unknown | 16 | 18% |