Title |
Estrogen-Related Receptors in Breast Cancer and Prostate Cancer
|
---|---|
Published in |
Frontiers in endocrinology, May 2015
|
DOI | 10.3389/fendo.2015.00083 |
Pubmed ID | |
Authors |
Aya Misawa, Satoshi Inoue |
Abstract |
Estrogen-signaling pathways are implicated in the development of breast cancer and prostate cancer. Various studies have focused on additional signaling pathways, mediated by estrogen-related receptors (ERRs). ERRs are constitutively active receptors that share a high degree of homology with the classical estrogen receptors (ERs). However, they do not bind to estrogen, while ERs do. ERRs are involved in the development of alternative pathways that lead to the development of cancer and are regarded as potential therapeutic targets for the treatment of breast cancer and prostate cancer that do not respond to conventional therapies. In this review, we first present general structural features of ERRs. Then, we focus on breast cancer and prostate cancer, which are primarily hormone-dependent cancers, and summarizes recent progress in elucidating the involvement of each ERR in these two types of malignancies. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 75 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 23% |
Student > Master | 8 | 11% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 6 | 8% |
Researcher | 5 | 7% |
Other | 12 | 16% |
Unknown | 20 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 20 | 27% |
Medicine and Dentistry | 8 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Agricultural and Biological Sciences | 5 | 7% |
Immunology and Microbiology | 3 | 4% |
Other | 10 | 13% |
Unknown | 23 | 31% |