Title |
Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review
|
---|---|
Published in |
Frontiers in Physiology, May 2018
|
DOI | 10.3389/fphys.2018.00574 |
Pubmed ID | |
Authors |
John K. Smith |
Abstract |
This review details the manner in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. It includes a review of the homeostatic contributions of neurons located in the hypothalamus, the midbrain and limbic structures, the pons and the medullary area postrema, nucleus tractus solitarius, and vagus nucleus, and details how these brain regions respond to circulating levels of orexigenic hormones, such as ghrelin, and anorexigenic hormones, such as glucagon-like peptide 1 and leptin. It provides an insight as to how high intensity exercise may improve homeostatic control in overweight and obese subjects. Finally, it provides suggestions as to how further progress can be made in controlling the current pandemic of obesity and diabetes. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 17 | 11% |
Mexico | 14 | 9% |
United States | 9 | 6% |
Canada | 2 | 1% |
Peru | 1 | <1% |
Paraguay | 1 | <1% |
Lebanon | 1 | <1% |
Namibia | 1 | <1% |
Greece | 1 | <1% |
Other | 5 | 3% |
Unknown | 100 | 66% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 104 | 68% |
Practitioners (doctors, other healthcare professionals) | 25 | 16% |
Scientists | 18 | 12% |
Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 94 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 18% |
Student > Ph. D. Student | 16 | 17% |
Student > Master | 11 | 12% |
Student > Bachelor | 9 | 10% |
Student > Doctoral Student | 5 | 5% |
Other | 14 | 15% |
Unknown | 22 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 15% |
Neuroscience | 12 | 13% |
Biochemistry, Genetics and Molecular Biology | 11 | 12% |
Agricultural and Biological Sciences | 9 | 10% |
Sports and Recreations | 8 | 9% |
Other | 17 | 18% |
Unknown | 23 | 24% |