Title |
miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function
|
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Published in |
Frontiers in Aging Neuroscience, April 2015
|
DOI | 10.3389/fnagi.2015.00061 |
Pubmed ID | |
Authors |
Juhyun Song, Jong Eun Lee |
Abstract |
Alzheimer's disease (AD) is considered the most common cause of sporadic dementia. In AD, adaptive and innate immune responses play a crucial role in clearance of amyloid beta and maintenance of cognitive functions. In addition to other changes in the immune system, AD alters the T-cell responses that affect activation of glial cells, neuronal cells, macrophages, and secretion of pro-inflammatory cytokines. These changes in the immune system influence AD pathogenesis. Micro-RNA (miRNA)-155 is a multifunctional miRNA with a distinct expression profile. It is involved in diverse physiological and pathological mechanisms, such as immunity and inflammation. Recent studies indicate that miR-155 regulates T-cell functions during inflammation. In this article, we summarize recent studies describing the therapeutic potential of miR-155 via regulation of T cells in AD. Further, we propose that regulation of miR-155 might be a new protective approach against AD pathogenesis. |
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Unknown | 1 | 100% |
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Mendeley readers
Geographical breakdown
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Denmark | 1 | 1% |
Austria | 1 | 1% |
Unknown | 87 | 98% |
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Researcher | 14 | 16% |
Student > Master | 10 | 11% |
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Student > Doctoral Student | 5 | 6% |
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Other | 10 | 11% |
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