Title |
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis
|
---|---|
Published in |
Frontiers in oncology, May 2015
|
DOI | 10.3389/fonc.2015.00108 |
Pubmed ID | |
Authors |
Xiao-Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer, Lan Wang |
Abstract |
Histone, and non-histone, protein acetylation plays an important role in a variety of cellular events, including the normal and abnormal development of blood cells, by changing the epigenetic status of chromatin and regulating non-histone protein function. Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members. HATs are not only protein modifiers and epigenetic factors but also critical regulators of cell development and carcinogenesis. Here, we will review the function of HATs such as p300/CBP, Tip60, MOZ/MORF, and GCN5/PCAF in normal hematopoiesis and the pathogenesis of hematological malignancies. The inhibitors that have been developed to target HATs will also be reviewed here. Understanding the roles of HATs in normal/malignant hematopoiesis will provide the potential therapeutic targets for the hematological malignancies. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 14% |
United States | 1 | 14% |
France | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 181 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 55 | 30% |
Student > Bachelor | 23 | 13% |
Student > Master | 19 | 10% |
Researcher | 15 | 8% |
Student > Doctoral Student | 8 | 4% |
Other | 19 | 10% |
Unknown | 42 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 68 | 38% |
Agricultural and Biological Sciences | 27 | 15% |
Chemistry | 9 | 5% |
Medicine and Dentistry | 7 | 4% |
Immunology and Microbiology | 6 | 3% |
Other | 17 | 9% |
Unknown | 47 | 26% |