Title |
The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
|
---|---|
Published in |
Frontiers in Molecular Biosciences, May 2018
|
DOI | 10.3389/fmolb.2018.00048 |
Pubmed ID | |
Authors |
Yury S. Polikanov, Nikolay A. Aleksashin, Bertrand Beckert, Daniel N. Wilson |
Abstract |
The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our current arsenal of ribosome-targeting antibiotics, highlighting the need for the discovery of compounds with new scaffolds that bind to novel sites on the ribosome. One possible avenue for the development of new antimicrobial agents is by characterization and optimization of ribosome-targeting peptide antibiotics. Biochemical and structural data on ribosome-targeting peptide antibiotics illustrates the large diversity of scaffolds, binding interactions with the ribosome as well as mechanism of action to inhibit translation. The availability of high-resolution structures of ribosomes in complex with peptide antibiotics opens the way to structure-based design of these compounds as novel antimicrobial agents. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 14% |
France | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 259 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 17% |
Student > Master | 40 | 15% |
Researcher | 32 | 12% |
Student > Bachelor | 32 | 12% |
Student > Doctoral Student | 10 | 4% |
Other | 29 | 11% |
Unknown | 72 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 78 | 30% |
Agricultural and Biological Sciences | 32 | 12% |
Chemistry | 24 | 9% |
Immunology and Microbiology | 16 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Other | 22 | 8% |
Unknown | 76 | 29% |