Title |
“Phage Transplantation in Allotransplantation”: Possible Treatment in Graft-Versus-Host Disease?
|
---|---|
Published in |
Frontiers in immunology, April 2018
|
DOI | 10.3389/fimmu.2018.00941 |
Pubmed ID | |
Authors |
Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski |
Abstract |
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD. |
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Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
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Unknown | 28 | 100% |
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Other | 2 | 7% |
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