Title |
Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
|
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Published in |
Frontiers in Microbiology, April 2018
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DOI | 10.3389/fmicb.2018.00730 |
Pubmed ID | |
Authors |
Krzysztof Łopata, Emilia Wojdas, Roman Nowak, Paweł Łopata, Urszula Mazurek |
Abstract |
The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells remains unknown. Although, to date, no PERV infections have been noted in vivo, the possibility of such infections has been confirmed in vitro. Better understanding of the structure and replication cycle of PERVs is a prerequisite for determining the risk of infection and planning PERV-detection strategies. This review presents the current state of knowledge about the structure and replication cycle of PERVs in the context of retroviral infection risk. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 19% |
Student > Master | 7 | 12% |
Student > Bachelor | 7 | 12% |
Student > Doctoral Student | 4 | 7% |
Researcher | 3 | 5% |
Other | 4 | 7% |
Unknown | 21 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 19% |
Agricultural and Biological Sciences | 7 | 12% |
Veterinary Science and Veterinary Medicine | 5 | 9% |
Medicine and Dentistry | 4 | 7% |
Immunology and Microbiology | 4 | 7% |
Other | 3 | 5% |
Unknown | 23 | 40% |