Title |
Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report
|
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Published in |
Frontiers in Neurology, May 2018
|
DOI | 10.3389/fneur.2018.00340 |
Pubmed ID | |
Authors |
Sara Gil-Perotin, Jéssica Castillo-Villalba, Joan Carreres-Polo, Arantxa Navarré-Gimeno, Javier Mallada-Frechín, Francisco Pérez-Miralles, Francisco Gascón, Carmen Alcalá-Vicente, Laura Cubas-Nuñez, Bonaventura Casanova-Estruch |
Abstract |
The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes [in the neuromyelitis optica spectrum disorders (NMOSD) and less frequently, in multiple sclerosis (MS)], but it has rarely been associated with the progressive course of disease. To contribute to the characterization of MOG-related demyelination, we describe the case of a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG. |
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