Title |
Immune response to gut Escherichia coli and susceptibility to adjuvant arthritis in the rats.
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Published in |
Acta Microbiologica et Immunologica Hungarica, March 2015
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DOI | 10.1556/amicr.62.2015.1.1 |
Pubmed ID | |
Authors |
Vesna Kovačević-Jovanović, Tatjana Miletić, Stanislava Stanojević, Katarina Mitić, Mirjana Dimitrijević |
Abstract |
We have investigated the humoral immune response to antigens of predominant gut aerobic bacterial strains (i.e. Escherichia coli) over the course of adjuvant arthritis and oil-induced arthritis in two inbred rat strains: Dark Agouti (DA) and Albino Oxford (AO). We report the presence of antibodies specific to proteins of E. coli in molecular weight range between 20-30 kDa in sera of diseased DA rats, and the absence of these antibodies in the sera of AO rats. In DA rats, CFA and IFA provoked a stronger antibody response to E. coli, especially of the IgG2b antibody class. Intramuscular administration of E. coli preceding the adjuvant arthritis induction had no effect on the development and course of disease, as well as on the activation of T cells in the draining inguinal lymph nodes. Higher serum levels of natural and induced IgA antibodies, combined with a higher CD3+CD26+ cell percentage were found in AO rats. The observed correlation between the serologic response to commensal flora and rats' genetic background as a defining factor for arthritis susceptibility may contribute to the process of creating a favorable (or less favorable) milieu for arthritis development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor > Associate Professor | 1 | 11% |
Student > Bachelor | 1 | 11% |
Researcher | 1 | 11% |
Other | 1 | 11% |
Unknown | 5 | 56% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 22% |
Biochemistry, Genetics and Molecular Biology | 1 | 11% |
Immunology and Microbiology | 1 | 11% |
Unknown | 5 | 56% |