Stimulation of naïve CD4 T cells with weak T cell receptor agonists even in the absence of T helper-skewing cytokines can result in IL-4 production which can drive a Th2 response. Evidence for the in vivo consequences of such a phenomenon can be found in a number of mouse models and, importantly, a series of monogenic human diseases associated with significant atopy which are caused by mutations in the T cell receptor signaling cascade. Such diseases can help understand how Th2 responses evolve in humans, and potentially provide insight into therapeutic interventions.
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
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#16,371,329
of 26,281,970 outputs
Outputs from Frontiers in immunology
#16,046
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#185,379
of 328,084 outputs
Outputs of similar age from Frontiers in immunology
#427
of 684 outputs
Altmetric has tracked 26,281,970 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,914 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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