Title |
EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
|
---|---|
Published in |
Frontiers in oncology, July 2015
|
DOI | 10.3389/fonc.2015.00162 |
Pubmed ID | |
Authors |
Florencia Cidre-Aranaz, Javier Alonso |
Abstract |
Ewing sarcoma is an aggressive bone malignancy that affect children and young adults. Ewing sarcoma is the second most common primary bone malignancy in pediatric patients. Although significant progress has been made in the treatment of Ewing sarcoma since it was first described in the 1920s, in the last decade survival rates have remained unacceptably invariable, thus pointing to the need for new approaches centered in the molecular basis of the disease. Ewing sarcoma driving mutation, EWS-FLI1, which results from a chromosomal translocation, encodes an aberrant transcription factor. Since its first characterization in 1990s, many molecular targets have been described to be regulated by this chimeric transcription factor. Their contribution to orchestrate Ewing sarcoma phenotype has been reported over the last decades. In this work, we will focus on the description of a selection of EWS/FLI1 targets, their functional role, and their potential clinical relevance. We will also discuss their role in other types of cancer as well as the need for further studies to be performed in order to achieve a broader understanding of their particular contribution to Ewing sarcoma development. |
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Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Unknown | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Turkey | 1 | <1% |
Italy | 1 | <1% |
Unknown | 141 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
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Student > Ph. D. Student | 25 | 17% |
Student > Master | 16 | 11% |
Researcher | 14 | 10% |
Student > Doctoral Student | 9 | 6% |
Other | 18 | 13% |
Unknown | 28 | 20% |
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Agricultural and Biological Sciences | 21 | 15% |
Immunology and Microbiology | 4 | 3% |
Engineering | 2 | 1% |
Other | 9 | 6% |
Unknown | 32 | 22% |