Title |
Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets
|
---|---|
Published in |
Frontiers in immunology, January 2015
|
DOI | 10.3389/fimmu.2015.00363 |
Pubmed ID | |
Authors |
Enric Gutiérrez-Martínez, Remi Planès, Giorgio Anselmi, Matthew Reynolds, Shinelle Menezes, Aimé Cézaire Adiko, Loredana Saveanu, Pierre Guermonprez |
Abstract |
Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8(+) T cells. There is strong in vivo evidence that the mouse XCR1(+) DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets. |
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