Title |
Targeting Head and Neck Cancer by Vaccination
|
---|---|
Published in |
Frontiers in immunology, April 2018
|
DOI | 10.3389/fimmu.2018.00830 |
Pubmed ID | |
Authors |
Chuan Wang, James Dickie, Ruhcha V. Sutavani, Catherine Pointer, Gareth J. Thomas, Natalia Savelyeva |
Abstract |
Head and neck cancer (HNC) is a heterogeneous group of squamous cell cancers that affect the oral cavity, pharynx, and larynx. Worldwide, it is the sixth most common cancer but in parts of Southern and South-East Asia, HNC is one of the most common cancers. A significant proportion of HNC is driven by human papillomavirus (HPV) infection, whereas HPV-independent HNC is associated with alcohol, smoking, and smokeless tobacco consumption. Here, we review the past and present experience of targeting HNC with vaccination focusing on HPV-derived antigens as well as non-viral antigens for HPV-negative HNC. Novel therapeutic approaches for HNC will focus not only on effective vaccine platforms but will also target the stroma-rich immunosuppressive microenvironment found in those tumours. |
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Country | Count | As % |
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Colombia | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 117 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 13 | 11% |
Student > Ph. D. Student | 13 | 11% |
Researcher | 12 | 10% |
Student > Bachelor | 11 | 9% |
Student > Doctoral Student | 10 | 9% |
Other | 23 | 20% |
Unknown | 35 | 30% |
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Agricultural and Biological Sciences | 4 | 3% |
Other | 12 | 10% |
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