Title |
Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review
|
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Published in |
Frontiers in Pharmacology, May 2018
|
DOI | 10.3389/fphar.2018.00522 |
Pubmed ID | |
Authors |
Mengqian Li, Liting You, Jianxin Xue, You Lu |
Abstract |
Cellular senescence is identified by a living cell in irreversible and persistent cell cycle arrest in response to various cellular stresses. Senescent cells secrete senescence-associated secretory phenotype factors that can amplify cellular senescence and alter the microenvironments. Radiotherapy, via ionizing radiation, serves as an effective treatment for local tumor control with side effects on normal cells, which can induce inflammation and fibrosis in irradiated and nearby regions. Research has revealed that senescent phenotype is observable in irradiated organs. This process starts with DNA damage mediated by radiation, after which a G2 arrest occurs in virtually all eukaryotic cells and a mitotic bypass is possibly necessary to ultimately establish cellular senescence. Within this complex DNA damage response signaling network, ataxia telangiectasia-mutated protein, p53, and p21 stand out as the crucial mediators. Senolytic agents, a class of small molecules that can selectively kill senescent cells, hold great potential to substantially reduce the side effects caused by radiotherapy while reasonably steer clear of carcinogenesis. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 164 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 31 | 19% |
Researcher | 24 | 15% |
Student > Bachelor | 17 | 10% |
Student > Master | 16 | 10% |
Student > Doctoral Student | 6 | 4% |
Other | 22 | 13% |
Unknown | 48 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 61 | 37% |
Agricultural and Biological Sciences | 19 | 12% |
Medicine and Dentistry | 11 | 7% |
Neuroscience | 5 | 3% |
Physics and Astronomy | 4 | 2% |
Other | 16 | 10% |
Unknown | 48 | 29% |