Title |
New Tools for Epilepsy Therapy
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, May 2018
|
DOI | 10.3389/fncel.2018.00147 |
Pubmed ID | |
Authors |
Chiara Falcicchia, Michele Simonato, Gianluca Verlengia |
Abstract |
One third of the epilepsies are refractory to conventional antiepileptic drugs (AEDs) and, therefore, identification of new therapies is highly needed. Here, we briefly describe two approaches, direct cell grafting and gene therapy, that may represent alternatives to conventional drugs for the treatment of focal epilepsies. In addition, we discuss more in detail some new tools, cell based-biodelivery systems (encapsulated cell biodelivery (ECB) devices) and new generation gene therapy vectors, which may help in the progress toward clinical translation. The field is advancing rapidly, and there is optimism that cell and/or gene therapy strategies will soon be ready for testing in drug-resistant epileptic patients. |
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Unknown | 4 | 100% |
Demographic breakdown
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 15% |
Student > Master | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Researcher | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 5 | 12% |
Unknown | 17 | 41% |
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Social Sciences | 2 | 5% |
Other | 3 | 7% |
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