Title |
IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis
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Published in |
Frontiers in Psychiatry, June 2018
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DOI | 10.3389/fpsyt.2018.00271 |
Pubmed ID | |
Authors |
Milica M. Borovcanin, Slavica M. Janicijevic, Ivan P. Jovanovic, Nevena Gajovic, Nebojsa N. Arsenijevic, Miodrag L. Lukic |
Abstract |
Schizophrenia and treatment of this disorder are often accompanied with metabolic syndrome and cardiovascular issues. Alterations in the serum level of innate immune mediators, such as interleukin-33 (IL-33) and its receptor IL-33R (ST2) and Galectin-3 (Gal-3) were observed in these conditions. Moreover, these parameters are potential prognostic and therapeutic markers. There is also accumulating evidence that these molecules play a role in neuroinflammation. Therefore, in this study we have investigated the serum level of Gal-3, IL-33 and soluble ST2 (sST2) in different stages of schizophrenia. Gal-3 levels were elevated in remission and lower in schizophrenia exacerbation in comparison with controls. Levels of IL-33 and sST2 are higher in schizophrenia exacerbation in comparison with controls and patients in remission. This initial analysis of new markers of neuroinflammation suggested their involvement in schizophrenia pathophysiology and/or cardiometabolic comorbidity. |
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Unknown | 3 | 100% |
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Mendeley readers
Geographical breakdown
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Unknown | 40 | 100% |
Demographic breakdown
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Lecturer | 4 | 10% |
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Other | 12 | 30% |
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Neuroscience | 3 | 8% |
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Unspecified | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 35% |