Title |
Anticipatory pleasure predicts effective connectivity in the mesolimbic system
|
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Published in |
Frontiers in Behavioral Neuroscience, August 2015
|
DOI | 10.3389/fnbeh.2015.00217 |
Pubmed ID | |
Authors |
Zhi Li, Chao Yan, Wei-Zhen Xie, Ke Li, Ya-Wei Zeng, Zhen Jin, Eric F. C. Cheung, Raymond C. K. Chan |
Abstract |
Convergent evidence suggests the important role of the mesolimbic pathway in anticipating monetary rewards. However, the underlying mechanism of how the sub-regions interact with each other is still not clearly understood. Using dynamic causal modeling, we constructed a reward-related network for anticipating monetary reward using the Monetary Incentive Delay Task. Twenty-six healthy adolescents (Female/Male = 11/15; age = 18.69 ± 1.35 years; education = 12 ± 1.58 years) participated in the present study. The best-fit network involved the right substantia nigra/ventral tegmental area (SN/VTA), the right nucleus accumbens (NAcc) and the right thalamus, which were all activated during anticipation of monetary gain and loss. The SN/VTA directly activates the NAcc and the thalamus. More importantly, monetary gain modulated the connectivity from the SN/VTA to the NAcc and this was significantly correlated with subjective anticipatory pleasure (r = 0.649, p < 0.001). Our findings suggest that activity in the mesolimbic pathway during the anticipation of monetary reward could to some extent be predicted by subjective anticipatory pleasure. |
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