Title |
Isolation and Synthesis of Misszrtine A: A Novel Indole Alkaloid From Marine Sponge-Associated Aspergillus sp. SCSIO XWS03F03
|
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Published in |
Frontiers in Chemistry, June 2018
|
DOI | 10.3389/fchem.2018.00212 |
Pubmed ID | |
Authors |
Rong Zhou, Xiaojian Liao, Hangbin Li, Jing Li, Pengju Feng, BingXin Zhao, Shihai Xu |
Abstract |
A novel indole alkaloid, misszrtine A (1), was isolated from marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. The planar structure of 1 was assigned by analysis of spectroscopic data, the absolute configuration of which was unambiguously determined by total synthesis. Compound 1 represents the first example of N-isopentenyl tryptophan methyl ester with a phenylpropanoic amide arm, which exhibited a potent antagonistic activity on HL60 (IC50 = 3.1 μM) and LNCaP (IC50 = 4.9 μM) cell lines. Bioactivity evaluation reveals that functional group on indole nitrogen of 1 has a great effect on its cytotoxity, which provides a mean to probe the structure-activity relationships of 1. |
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Unknown | 1 | 100% |
Demographic breakdown
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 27% |
Researcher | 3 | 14% |
Other | 2 | 9% |
Lecturer | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 3 | 14% |
Unknown | 4 | 18% |
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Immunology and Microbiology | 3 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 2 | 9% |
Unknown | 5 | 23% |