Title |
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis
|
---|---|
Published in |
Frontiers in endocrinology, June 2018
|
DOI | 10.3389/fendo.2018.00322 |
Pubmed ID | |
Authors |
Konstantinos Lontos, Juraj Adamik, Anastasia Tsagianni, Deborah L. Galson, John M. Chirgwin, Attaya Suvannasankha |
Abstract |
Semaphorin 4D (Sema4D; CD100) is a transmembrane homodimer 150-kDa glycoprotein member of the Semaphorin family. Semaphorins were first identified as chemorepellants that guide neural axon growth. Sema4D also possesses immune regulatory activity. Recent data suggest other Sema4D functions: inactivation of platelets, stimulation of angiogenesis, and regulation of bone formation. Sema4D is a coupling factor expressed on osteoclasts that inhibits osteoblast differentiation. Blocking Sema4D may, therefore, be anabolic for bone. Sema4D and its receptor Plexin-B1 are commonly dysregulated in cancers, suggesting roles in cancer progression, invasion, tumor angiogenesis, and skeletal metastasis. This review focuses on Sema4D in bone and cancer biology and the molecular pathways involved, particularly Sema4D-Plexin-B1 signaling crosstalk between cancer cells and the bone marrow microenvironment-pertinent areas since a humanized Sema4D-neutralizing antibody is now in early phase clinical trials in cancers and neurological disorders. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 22% |
Student > Master | 7 | 14% |
Researcher | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 5 | 10% |
Unknown | 18 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 27% |
Medicine and Dentistry | 6 | 12% |
Agricultural and Biological Sciences | 3 | 6% |
Computer Science | 1 | 2% |
Immunology and Microbiology | 1 | 2% |
Other | 5 | 10% |
Unknown | 21 | 41% |