Title |
At the frontier of epigenetics of brain sex differences
|
---|---|
Published in |
Frontiers in Behavioral Neuroscience, August 2015
|
DOI | 10.3389/fnbeh.2015.00221 |
Pubmed ID | |
Authors |
Margaret M. McCarthy, Bridget M. Nugent |
Abstract |
The notion that epigenetics may play an important role in the establishment and maintenance of sex differences in the brain has garnered great enthusiasm but the reality in terms of actual advances has been slow. Two general approaches include the comparison of a particular epigenetic mark in males vs. females and the inhibition of key epigenetic enzymes or co-factors to determine if this eliminates a particular sex difference in brain or behavior. The majority of emphasis has been on candidate genes such as steroid receptors. Only recently have more generalized survey type approaches been achieved and these promise to open new vistas and accelerate discovery of important roles for DNA methylation, histone modification, genomic imprinting and microRNAs (miRs). Technical challenges abound and, while not unique to this field, will require novel thinking and new approaches by behavioral neuroendocrinologists. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 21% |
Canada | 2 | 14% |
Australia | 1 | 7% |
Switzerland | 1 | 7% |
Unknown | 7 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 79% |
Scientists | 3 | 21% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 150 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 23% |
Researcher | 32 | 21% |
Student > Master | 18 | 12% |
Student > Bachelor | 15 | 10% |
Professor > Associate Professor | 10 | 6% |
Other | 22 | 14% |
Unknown | 22 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 36 | 23% |
Agricultural and Biological Sciences | 31 | 20% |
Biochemistry, Genetics and Molecular Biology | 19 | 12% |
Psychology | 11 | 7% |
Medicine and Dentistry | 11 | 7% |
Other | 16 | 10% |
Unknown | 30 | 19% |