Title |
Human αβ and γδ T Cells in Skin Immunity and Disease
|
---|---|
Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01304 |
Pubmed ID | |
Authors |
Michelle S. Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson |
Abstract |
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata. Understanding the contribution of skin-resident and skin-infiltrating T cell populations and cross-talk with other immune cells is leading to the development of novel therapeutics for patients. However, there is still much to be learned in order to effectively modulate T cell function and maintain healthy skin homeostasis. |
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Geographical breakdown
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