Title |
The Clinical Landscape of Circulating Tumor DNA in Gastrointestinal Malignancies
|
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Published in |
Frontiers in oncology, July 2018
|
DOI | 10.3389/fonc.2018.00263 |
Pubmed ID | |
Authors |
Kentaro Sawada, Daisuke Kotani, Hideaki Bando |
Abstract |
Technologies for genomic analyses have revealed more details in cancer biology and have changed standard treatments for cancer, including the introduction of targeted gene-specific therapy. Currently, liquid biopsies are increasingly being utilized in clinical trials and research settings to analyze circulating tumor DNA (ctDNA) from peripheral blood. Several studies have shown the potential of ctDNA in the screening, prognostication, molecular profiling, and monitoring of gastrointestinal malignancies. Although limitations continue to exist in the use of ctDNA, such as method standardization, the sensitivity, concordance with tumor tissue, and regulatory issues, this field offers promising benefits for cancer treatment. A deeper understanding of tumor biology via ctDNA analyses and ctDNA-guided clinical trials will lead to the increasing use of ctDNA in clinical practice in the near future; this development will result in the improvement of outcomes among patients with gastrointestinal malignancies. |
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Geographical breakdown
Country | Count | As % |
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United States | 3 | 75% |
Switzerland | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 9 | 23% |
Student > Ph. D. Student | 7 | 18% |
Researcher | 6 | 15% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 2 | 5% |
Other | 1 | 3% |
Unknown | 10 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Nursing and Health Professions | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Economics, Econometrics and Finance | 3 | 8% |
Other | 2 | 5% |
Unknown | 11 | 28% |