Title |
Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation
|
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Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01110 |
Pubmed ID | |
Authors |
Daniel Peltier, Pavan Reddy |
Abstract |
Allogeneic bone marrow transplantation (BMT) is an effective therapy for several malignant and non-malignant disorders. The precise control of allogeneic T cells is critical for successful outcomes after BMT. The mechanisms governing desirable (graft-versus-leukemia) versus undesirable (graft-versus-host disease) allogeneic responses remain incompletely understood. Non-coding RNAs (ncRNA) are controllers of gene expression that fine-tune cellular responses. Multiple microRNAs (miRNAs), a type of ncRNA, have recently been shown to influence allogeneic T cell responses in both murine models and clinically. Here, we review the role of various miRNAs that regulate T cell responses, either positively or negatively, to allo-stimulation and highlight their potential relevance as biomarkers and as therapeutic targets for improving outcomes after allogeneic BMT. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 24% |
Researcher | 3 | 18% |
Student > Ph. D. Student | 3 | 18% |
Unspecified | 1 | 6% |
Other | 1 | 6% |
Other | 2 | 12% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 4 | 24% |
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Unspecified | 1 | 6% |
Engineering | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 18% |